RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Histamine-induced vascular leakage is an integral component of many highly prevalent human diseases, including allergies, asthma, and anaphylaxis. Yet, how histamine induces the disruption of the endothelial barrier is not well defined. By using genetically modified animal models, pharmacologic inhi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mikelis, Constantinos M., Simaan, May, Ando, Koji, Fukuhara, Shigetomo, Sakurai, Atsuko, Amornphimoltham, Panomwat, Masedunskas, Andrius, Weigert, Roberto, Chavakis, Triantafyllos, Adams, Ralf, Offermanns, Stefan, Mochizuki, Naoki, Zheng, Yi, Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394241/
https://ncbi.nlm.nih.gov/pubmed/25857352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7725
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