RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Histamine-induced vascular leakage is an integral component of many highly prevalent human diseases, including allergies, asthma, and anaphylaxis. Yet, how histamine induces the disruption of the endothelial barrier is not well defined. By using genetically modified animal models, pharmacologic inhi...

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Publié dans:Nat Commun
Auteurs principaux: Mikelis, Constantinos M., Simaan, May, Ando, Koji, Fukuhara, Shigetomo, Sakurai, Atsuko, Amornphimoltham, Panomwat, Masedunskas, Andrius, Weigert, Roberto, Chavakis, Triantafyllos, Adams, Ralf, Offermanns, Stefan, Mochizuki, Naoki, Zheng, Yi, Gutkind, J. Silvio
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394241/
https://ncbi.nlm.nih.gov/pubmed/25857352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7725
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