Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an a...

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Detalhes bibliográficos
Publicado no:Genomics Inform
Main Authors: John, Arun, Umashankar, Vetrivel, Krishnakumar, Subramanian, Deepa, Perinkulam Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: Korea Genome Organization 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394236/
https://ncbi.nlm.nih.gov/pubmed/25873848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5808/GI.2015.13.1.15
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