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A molecular model of human Lysyl Oxidase (LOX) with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators

Lysyl oxidase (LOX) is a copper dependent amine oxidase which catalyses the cross linking of collagen and elastin towards the maturation of extracellular matrix. The expression and activity of LOX is known to vary under pathological conditions such as tumorigenesis, hyperhomocysteinemia, copper defi...

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Bibliografske podrobnosti
Main Authors: Bhuvanasundar, Renganathan, John, Arun, Sulochana, Konerirajapuram Natarajan, Coral, Karunakaran, Deepa, Perinkulam Ravi, Umashankar, Vetrivel
Format: Artigo
Jezik:Inglês
Izdano: Biomedical Informatics 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135287/
https://ncbi.nlm.nih.gov/pubmed/25187679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630010406
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