Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes

The Epstein–Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP1) constitutively activates nuclear factor κB (NFκB) from intracellular membranes to promote cell growth and survival. LMP1 associates with CD63 in intracellular membranes and is released via exosomes. Whether tumour necr...

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Detalles Bibliográficos
Publicado en:J Extracell Vesicles
Main Authors: Verweij, Frederik J., de Heus, Cecilia, Kroeze, Stefanie, Cai, Houjian, Kieff, Elliott, Piersma, Sander R., Jimenez, Connie R., Middeldorp, Jaap M., Pegtel, Dirk Michiel
Formato: Artigo
Idioma:Inglês
Publicado: Co-Action Publishing 2015
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Original Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394166/
https://ncbi.nlm.nih.gov/pubmed/25865256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/jev.v4.26334
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