Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells

5-Fluorouracil (FU) is a halogenated nucleobase analog that is widely used in chemotherapy. Here we show that 5-hydroxymethyl-2′-deoxyuridine (hmUdR) synergistically enhances the activity of FU in cell lines derived from solid tumors but not normal tissues. While the cytotoxicity of FU and hmUdR was...

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Publicat a:Oncoscience
Autors principals: Matsumoto, Yoshihiro, Rodriguez, Victoria, Whitford, Tracy A., Beeharry, Neil, Ide, Hiroshi, Tomkinson, Alan E.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394133/
https://ncbi.nlm.nih.gov/pubmed/25897430
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