The p53–PUMA axis suppresses iPSC generation

Mechanisms underlying the reprogramming process of induced pluripotent stem cells remain poorly defined. Like tumorigenesis, generation of induced pluripotent stem cells was shown to be suppressed by the Trp53 (p53) pathway, at least in part via p21(Cdkn1a) (p21)-mediated cell cycle arrest. Here we...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Li, Yanxin, Feng, Haizhong, Gu, Haihui, Lewis, Dale W., Yuan, Youzhong, Zhang, Lei, Yu, Hui, Zhang, Peng, Cheng, Haizi, Miao, Weimin, Yuan, Weiping, Cheng, Shi-Yuan, Gollin, Susanne M., Cheng, Tao
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394110/
https://ncbi.nlm.nih.gov/pubmed/23873265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3174
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