Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth

Ovarian carcinoma (OC) is the fifth leading cause of death among women in the United States. Persistent activation of signal transducer and activator of transcription (STAT3) is frequently detected in OC. STAT3 is activated by Janus family kinases (JAK) via cytokine receptors, growth factor receptor...

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Udgivet i:Mol Cancer Ther
Main Authors: Gritsina, Galina, Xiao, Fang, O'Brien, Shane W., Gabbasov, Rashid, Maglaty, Marisa A., Xu, Ren-Huan, Thapa, Roshan J., Zhou, Yan, Nicolas, Emmanuelle, Litwin, Samuel, Balachandran, Siddharth, Sigal, Luis J., Huszar, Dennis, Connolly, Denise C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394029/
https://ncbi.nlm.nih.gov/pubmed/25646015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0800
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