Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth

Ovarian carcinoma (OC) is the fifth leading cause of death among women in the United States. Persistent activation of signal transducer and activator of transcription (STAT3) is frequently detected in OC. STAT3 is activated by Janus family kinases (JAK) via cytokine receptors, growth factor receptor...

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Pubblicato in:Mol Cancer Ther
Autori principali: Gritsina, Galina, Xiao, Fang, O'Brien, Shane W., Gabbasov, Rashid, Maglaty, Marisa A., Xu, Ren-Huan, Thapa, Roshan J., Zhou, Yan, Nicolas, Emmanuelle, Litwin, Samuel, Balachandran, Siddharth, Sigal, Luis J., Huszar, Dennis, Connolly, Denise C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394029/
https://ncbi.nlm.nih.gov/pubmed/25646015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0800
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