Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition

Pharmacological inhibition of PARP is a promising approach in treating high grade serous ovarian carcinoma (HGSOC). PARP inhibitors (PARPi) are most active in patients with defects in DNA damage repair (DDR) mechanisms, such as alterations in expression/function of DNA repair and homologous recombin...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Gabbasov, Rashid, Benrubi, I. Daniel, O’Brien, Shane W., Krais, John J., Johnson, Neil, Litwin, Samuel, Connolly, Denise C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606007/
https://ncbi.nlm.nih.gov/pubmed/30929564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1595279
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