Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition

Pharmacological inhibition of PARP is a promising approach in treating high grade serous ovarian carcinoma (HGSOC). PARP inhibitors (PARPi) are most active in patients with defects in DNA damage repair (DDR) mechanisms, such as alterations in expression/function of DNA repair and homologous recombin...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Gabbasov, Rashid, Benrubi, I. Daniel, O’Brien, Shane W., Krais, John J., Johnson, Neil, Litwin, Samuel, Connolly, Denise C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606007/
https://ncbi.nlm.nih.gov/pubmed/30929564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1595279
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