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An NAD Synthetic Reaction Bypasses the Lipoate Requirement for Aerobic Growth of Escherichia coli Strains Blocked in Succinate Catabolism

The lipoate coenzyme is essential for function of the pyruvate (PDH) and 2-oxoglutarate (OGDH) dehydrogenases and thus for aerobic growth of Escherichia coli. LipB catalyzes the first step in lipoate synthesis, transfer of an octanoyl moiety from the fatty acid synthetic intermediate, octanoyl-ACP,...

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Bibliografiske detaljer
Udgivet i:Mol Microbiol
Main Authors: Hermes, Fatemah A., Cronan, John E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393350/
https://ncbi.nlm.nih.gov/pubmed/25303731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12822
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