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Scavenging of Cytosolic Octanoic Acid by Mutant LplA Lipoate Ligases Allows Growth of Escherichia coli Strains Lacking the LipB Octanoyltransferase of Lipoic Acid Synthesis

The LipB octanoyltransferase catalyzes the first step of lipoic acid synthesis in Escherichia coli, transfer of the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the E2 subunits of the 2-oxoacid dehydrogenases of aerobic metabolism. Strains containing null mutations in...

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Auteurs principaux: Hermes, Fatemah A. M., Cronan, John E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772501/
https://ncbi.nlm.nih.gov/pubmed/19684135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00798-09
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