Phase I Study of Oral Abexinostat, a Histone Deacetylase Inhibitor, in Combination with Doxorubicin in Patients with Metastatic Sarcoma

INTRODUCTION: Several inhibitors of histone deacetylase have been shown to enhance chemotherapy induced apoptosis and reduce sarcoma tumor volume in preclinical models. We sought to determine the MTD, PK/PD, safety and toxicity of the histone deacetylase inhibitor (HDACi) abexinostat (PCI-24781) whe...

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Pubblicato in:Cancer
Autori principali: Choy, Edwin, Flamand, Yael, Balasubramanian, Sriram, Butrynski, James E., Harmon, David C., George, Suzanne, Cote, Gregory M., Wagner, Andrew J., Morgan, Jeffrey A., Sirisawad, Mint, Mani, Chitra, Hornicek, Francis J., Duan, Zhenfeng, Demetri, George D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393337/
https://ncbi.nlm.nih.gov/pubmed/25536954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29175
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