The Histone Deacetylase Inhibitor PCI-24781 Induces Caspase and ROS-Dependent Apoptosis Through NF-kB and is Synergistic with Bortezomib in Lymphoma Cells

PURPOSE: We investigated the cytotoxicity and mechanisms of cell death of the broad-spectrum histone deacetylase inhibitor (HDACi), PCI-24781, alone and combined with bortezomib in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) cell lines and primary lymphoproliferative (CLL/SLL) cells. EXPERI...

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Main Authors: Bhalla, Savita, Balasubramanian, Sriram, David, Kevin, Sirisawad, Mint, Buggy, Joseph, Mauro, Lauren, Prachand, Sheila, Miller, Richard, Gordon, Leo I., Evens, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704489/
https://ncbi.nlm.nih.gov/pubmed/19417023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2365
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