SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness

Converting single-stranded viral RNA into double stranded DNA for integration is an essential step in HIV-1 replication. Initial polymerization of minus-strand DNA is primed from a host derived tRNA, whereas subsequent plus-strand synthesis requires viral primers derived from the 3′ and central poly...

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Publicado en:PLoS One
Main Authors: Rausch, Jason W., Tian, Meijuan, Li, Yuejin, Angelova, Lora, Bagaya, Bernard S., Krebs, Kendall C., Qian, Feng, Zhu, Chuanwu, Arts, Eric J., Le Grice, Stuart F. J., Gao, Yong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393142/
https://ncbi.nlm.nih.gov/pubmed/25860884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122953
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