tRNA(Glu) Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications

For tRNA-dependent protein biosynthesis, amino acids are first activated by aminoacyl-tRNA synthetases (aaRSs) yielding the reaction intermediates aminoacyl-AMP (aa-AMP). Stable analogues of aa-AMP, such as aminoacyl-sulfamoyl-adenosines, inhibit their cognate aaRSs. Glutamyl-sulfamoyl-adenosine (Gl...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Blais, Sébastien P., Kornblatt, Jack A., Barbeau, Xavier, Bonnaure, Guillaume, Lagüe, Patrick, Chênevert, Robert, Lapointe, Jacques
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393105/
https://ncbi.nlm.nih.gov/pubmed/25860020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121043
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