Biochemical Studies on Methylglyoxal-Mediated Glycated Histones: Implications for Presence of Serum Antibodies against the Glycated Histones in Patients with Type 1 Diabetes Mellitus

Reactive carbonyl species (RCS) mainly reacts with lysine and arginine residues of proteins to form advanced glycation end products (AGEs). Histone was glycoxidated with glyoxal and methylglyoxal. It was characterized by polyacrylamide gel electrophoresis and quenching studies involving penicillamin...

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Bibliographic Details
Published in:ISRN Biochem
Main Authors: Ansari, Nadeem A., Dash, Debabrata
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392999/
https://ncbi.nlm.nih.gov/pubmed/25937957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/198065
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