Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Movérare-Skrtic, Sofia, Henning, Petra, Liu, Xianwen, Nagano, Kenichi, Saito, Hiroaki, Börjesson, Anna E, Sjögren, Klara, Windahl, Sara H, Farman, Helen, Kindlund, Bert, Engdahl, Cecilia, Koskela, Antti, Zhang, Fu-Ping, Eriksson, Emma E, Zaman, Farasat, Hammarstedt, Ann, Isaksson, Hanna, Bally, Marta, Kassem, Ali, Lindholm, Catharina, Sandberg, Olof, Aspenberg, Per, Sävendahl, Lars, Feng, Jian Q, Tuckermann, Jan, Tuukkanen, Juha, Poutanen, Matti, Baron, Roland, Lerner, Ulf H, Gori, Francesca, Ohlsson, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392888/
https://ncbi.nlm.nih.gov/pubmed/25306233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3654
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