Displacement of Cortisol From Human Heart by Acute Administration of a Mineralocorticoid Receptor Antagonist

CONTEXT: Mineralocorticoid receptor (MR) antagonists have beneficial effects in patients with heart failure and myocardial infarction, often attributed to blocking aldosterone action in the myocardium. However, binding of aldosterone to MR requires local activity of the enzyme 11β-hydroxysteroid deh...

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Vydáno v:J Clin Endocrinol Metab
Hlavní autoři: Iqbal, Javaid, Andrew, Ruth, Cruden, Nicholas L., Kenyon, Christopher J., Hughes, Katherine A., Newby, David E., Hadoke, Patrick W. F., Walker, Brian R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392799/
https://ncbi.nlm.nih.gov/pubmed/24423282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-2049
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