Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9

The transcription factor Pdx1 is crucial to islet β cell function and regulates target genes in part through interaction with coregulatory factors. Set7/9 is a Lys methyltransferase that interacts with Pdx1. Here we tested the hypothesis that Lys methylation of Pdx1 by Set7/9 augments Pdx1 transcrip...

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Udgivet i:J Biol Chem
Main Authors: Maganti, Aarthi V., Maier, Bernhard, Tersey, Sarah A., Sampley, Megan L., Mosley, Amber L., Özcan, Sabire, Pachaiyappan, Boobalan, Woster, Patrick M., Hunter, Chad S., Stein, Roland, Mirmira, Raghavendra G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392279/
https://ncbi.nlm.nih.gov/pubmed/25713082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616219
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