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Activated α(2)-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses
Ligation of cell surface GRP78 by activated α(2)-macroglobulin (α(2)M*) promotes cell proliferation and suppresses apoptosis. α(2)M*-treated human prostate cancer cells exhibit a 2–3-fold increase in glucose uptake and lactate secretion, an effect similar to insulin treatment. In both α(2)M* and ins...
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| Publicado en: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392261/ https://ncbi.nlm.nih.gov/pubmed/25720493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617837 |
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