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Receptor-Recognized α(2)-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells

OBJECTIVE: Tetrameric α(2)-macroglobulin (α(2)M), a plasma panproteinase inhibitor, is activated upon interaction with a proteinase, and undergoes a major conformational change exposing a receptor recognition site in each of its subunits. Activated α(2)M (α(2)M*) binds to cancer cell surface GRP78 a...

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Autors principals: Misra, Uma K., Pizzo, Salvatore V.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522726/
https://ncbi.nlm.nih.gov/pubmed/23272152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051735
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