The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

Atypical hemolytic uremic syndrome (aHUS) is characterized by complement attack against host cells due to mutations in complement proteins or autoantibodies against complement factor H (CFH). It is unknown why nearly all patients with autoimmune aHUS lack CFHR1 (CFH-related protein-1). These patient...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bhattacharjee, Arnab, Reuter, Stefanie, Trojnár, Eszter, Kolodziejczyk, Robert, Seeberger, Harald, Hyvärinen, Satu, Uzonyi, Barbara, Szilágyi, Ágnes, Prohászka, Zoltán, Goldman, Adrian, Józsi, Mihály, Jokiranta, T. Sakari
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392255/
https://ncbi.nlm.nih.gov/pubmed/25659429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630871
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