Recognition of Malondialdehyde-modified Proteins by the C Terminus of Complement Factor H Is Mediated via the Polyanion Binding Site and Impaired by Mutations Found in Atypical Hemolytic Uremic Syndrome

Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy characterized by uncontrolled complement activation against endothelial and blood cells. Mutations in the C-terminal target recognition domains 19–20 of complement regulator factor H (FH) are strongly associated with aH...

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Bibliographische Detailangaben
Hauptverfasser: Hyvärinen, Satu, Uchida, Koji, Varjosalo, Markku, Jokela, Reija, Jokiranta, T. Sakari
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924292/
https://ncbi.nlm.nih.gov/pubmed/24344133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527416
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