Recognition of Malondialdehyde-modified Proteins by the C Terminus of Complement Factor H Is Mediated via the Polyanion Binding Site and Impaired by Mutations Found in Atypical Hemolytic Uremic Syndrome

Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy characterized by uncontrolled complement activation against endothelial and blood cells. Mutations in the C-terminal target recognition domains 19–20 of complement regulator factor H (FH) are strongly associated with aH...

Full description

Saved in:
Bibliographic Details
Main Authors: Hyvärinen, Satu, Uchida, Koji, Varjosalo, Markku, Jokela, Reija, Jokiranta, T. Sakari
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924292/
https://ncbi.nlm.nih.gov/pubmed/24344133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527416
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items