Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome

INTRODUCTION: In autoimmune atypical hemolytic uremic syndrome (aHUS), the complement regulator factor H (FH) is blocked by FH autoantibodies, while 90% of the patients carry a homozygous deletion of its homolog complement FH-related protein 1 (CFHR1). The functional consequence of FH-blockade is wi...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Trojnár, Eszter, Józsi, Mihály, Uray, Katalin, Csuka, Dorottya, Szilágyi, Ágnes, Milosevic, Danko, Stojanović, Vesna D., Spasojević, Brankica, Rusai, Krisztina, Müller, Thomas, Arbeiter, Klaus, Kelen, Kata, Szabó, Attila J., Reusz, György S., Hyvärinen, Satu, Jokiranta, T. Sakari, Prohászka, Zoltán
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371605/
https://ncbi.nlm.nih.gov/pubmed/28424685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00302
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