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IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5

IκB kinase β (IKKβ) is a catalytic subunit of the IKK complex, which activates nuclear factor-κB (NF-κB). Although its role in osteoclastogenesis is well established, the role of IKKβ in bone formation is poorly understood. Here, we report that conditional knockout of Ikkβ in limb bud mesenchymal ce...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Kobayashi, K, Toguchida, J, Karin, M, Kato, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392083/
https://ncbi.nlm.nih.gov/pubmed/25526093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.192
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