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Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays
Protein C (PC) is a vitamin K–dependent plasma glycoprotein, which upon activation by thrombin in complex with thrombomodulin (TM), regulates the coagulation cascade through a feedback loop inhibition mechanism. PC deficiency is associated with an increased risk of venous thromboembolism (VTE). A re...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392011/ https://ncbi.nlm.nih.gov/pubmed/25651845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-617274 |
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