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Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites

Evolutionary-rate variation among sites within proteins depends on functional and biophysical properties that constrain protein evolution. It is generally accepted that proteins must be able to fold stably in order to function. However, the relationship between stability constraints and among-sites...

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Pubblicato in:Phys Biol
Autori principali: Echave, Julian, Jackson, Eleisha L., Wilke, Claus O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391963/
https://ncbi.nlm.nih.gov/pubmed/25787027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/1478-3975/12/2/025002
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