Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent

Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon cells are located in NS5A, suggesting that NS5A is t...

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Publicado en:PLoS One
Autores principales: Kwon, Hyock Joo, Xing, Weimei, Chan, Katie, Niedziela-Majka, Anita, Brendza, Katherine M., Kirschberg, Thorsten, Kato, Darryl, Link, John O., Cheng, Guofeng, Liu, Xiaohong, Sakowicz, Roman
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391872/
https://ncbi.nlm.nih.gov/pubmed/25856426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122844
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