The Macroscopic Rate of Nucleic Acid Translocation by Hepatitis C virus Helicase NS3h is Dependent on Both the Sugar and Base Moieties

The NS3 helicase (NS3h) of hepatitis C virus (HCV) is a 3′ to 5′ SF2 RNA and DNA helicase that is essential for the replication of HCV. We have examined the kinetic mechanism of translocation of NS3h along single-stranded nucleic acid with bases rU, dU and dT and have found that the macroscopic rate...

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Main Authors: Khaki, Ali R., Field, Cassandra, Malik, Shuja, Niedziela-Majka, Anita, Leavitt, Stephanie A., Wang, Ruth, Hung, Magdeleine, Sakowicz, Roman, Brendza, Katherine M., Fischer, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902667/
https://ncbi.nlm.nih.gov/pubmed/20451531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.065
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