The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation

BACKGROUND: In mammals, X chromosome genes are present in one copy in males and two in females. To balance the dosage of X-linked gene expression between the sexes, one of the X chromosomes in females is silenced. X inactivation is initiated by upregulation of the lncRNA (long non-coding RNA) Xist a...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Yang, Fan, Deng, Xinxian, Ma, Wenxiu, Berletch, Joel B, Rabaia, Natalia, Wei, Gengze, Moore, James M, Filippova, Galina N, Xu, Jun, Liu, Yajuan, Noble, William S, Shendure, Jay, Disteche, Christine M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391730/
https://ncbi.nlm.nih.gov/pubmed/25887447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0618-0
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