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Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts, separated by a hinge region. Using Hi-C in edited mouse cells with allelic deletions or inversions within the hinge, here we show that the conserved Dxz4 locus is nece...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899087/ https://ncbi.nlm.nih.gov/pubmed/29654302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03694-y |
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