A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

Most p53 mutations in human cancers are missense mutations resulting in a full-length mutant p53 protein. Besides losing tumor suppressor activity, some hotspot p53 mutants gain oncogenic functions. This effect is mediated in part, through gene expression changes due to inhibition of p63 and p73 by...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Subramanian, M, Francis, P, Bilke, S, Li, XL, Hara, T, Lu, X, Jones, MF, Walker, RL, Zhu, Y, Pineda, M, Lee, C, Varanasi, L, Yang, Y, Martinez, LA, Luo, J, Ambs, S, Sharma, S, Wakefield, LM, Meltzer, PS, Lal, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391367/
https://ncbi.nlm.nih.gov/pubmed/24662829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.46
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