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Acute and Chronic Efficacy of Bumetanide in an in vitro Model of Posttraumatic Epileptogenesis

BACKGROUND: Seizures triggered by acute injuries to the developing brain respond poorly to first‐line medications that target the inhibitory chloride‐permeable GABA(A) receptor. Neuronal injury is associated with profound increases in cytoplasmic chloride ([Cl(−)](i)) resulting in depolarizing GABA...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Dzhala, Volodymyr, Staley, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391014/
https://ncbi.nlm.nih.gov/pubmed/25495911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12369
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