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Acute and Chronic Efficacy of Bumetanide in an in vitro Model of Posttraumatic Epileptogenesis
BACKGROUND: Seizures triggered by acute injuries to the developing brain respond poorly to first‐line medications that target the inhibitory chloride‐permeable GABA(A) receptor. Neuronal injury is associated with profound increases in cytoplasmic chloride ([Cl(−)](i)) resulting in depolarizing GABA...
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| Veröffentlicht in: | CNS Neurosci Ther |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4391014/ https://ncbi.nlm.nih.gov/pubmed/25495911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12369 |
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