PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation

BACKGROUND: Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in hepatocellular carcinoma proliferation (HCC). In this study we evaluated differences in the antiproliferative effect of dual PI3 K/Akt/mTOR and Ras/Raf/mitogen-activated protein...

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Bibliographic Details
Published in:J Surg Res
Main Authors: Gedaly, Roberto, Galuppo, Roberto, Musgrave, Yolanda, Angulo, Paul, Hundley, Jonathan, Shah, Malay, Daily, Michael F., Chen, Changguo, Cohen, Donald A., Spear, Brett T., Evers, B. Mark
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390173/
https://ncbi.nlm.nih.gov/pubmed/23769634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.05.016
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