Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease

BACKGROUND: The characteristic clinical heterogeneity and mostly slow-growing behavior of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) cause problems in finding appropriate treatments. Thus, the current therapy options are not satisfactory. PKI-587 is a highly potent, novel dual inhibi...

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Pubblicato in:Neuroendocrinology
Autori principali: Freitag, Helma, Christen, Friederike, Lewens, Florentine, Grass, Irina, Briest, Franziska, Iwaszkiewicz, Sara, Siegmund, Britta, Grabowski, Patricia
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2017
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475233/
https://ncbi.nlm.nih.gov/pubmed/27513674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000448843
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