AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells

BACKGROUND: Leukemic stem cells (LSCs) are frequently seen as a cause of treatment failure and relapse in patients with acute myeloid leukemia (AML). Thus, successful new therapeutic strategies for the treatment of AML should aim at eradicating LSCs. The identification of targets on the cell surface...

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Detalles Bibliográficos
Publicado en:J Hematol Oncol
Main Authors: Fan, Dongmei, Li, Zhenzhen, Zhang, Xiaolong, Yang, Yuqi, Yuan, Xiangfei, Zhang, Xiuli, Yang, Ming, Zhang, Yizhi, Xiong, Dongsheng
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389834/
https://ncbi.nlm.nih.gov/pubmed/25879549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0109-5
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