AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells

BACKGROUND: Leukemic stem cells (LSCs) are frequently seen as a cause of treatment failure and relapse in patients with acute myeloid leukemia (AML). Thus, successful new therapeutic strategies for the treatment of AML should aim at eradicating LSCs. The identification of targets on the cell surface...

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Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Fan, Dongmei, Li, Zhenzhen, Zhang, Xiaolong, Yang, Yuqi, Yuan, Xiangfei, Zhang, Xiuli, Yang, Ming, Zhang, Yizhi, Xiong, Dongsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389834/
https://ncbi.nlm.nih.gov/pubmed/25879549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0109-5
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