Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells

BACKGROUND: B-acute lymphoblastic leukemia (B-ALL) is derived from B cell progenitors. Recently, the development of appropriate combinations of chemotherapy and immunotherapy represents a promising approach for eliminating cancer. We previously constructed an anti-CD3 × anti-CD19 bi-specific antibod...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Fan, Dongmei, Li, Wei, Yang, Yuqi, Zhang, Xiaolong, Zhang, Qing, Yan, Yan, Yang, Ming, Wang, Jianxiang, Xiong, Dongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596481/
https://ncbi.nlm.nih.gov/pubmed/26444983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0205-6
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