Increased microtubule assembly rates mediate chromosomal instability in colorectal cancer cells

Chromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer. However, the mechanisms causing CIN and its consequences on tumor growth are largely unknown. We identify an increase in microtubule plus end assemb...

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Bibliographic Details
Published in:Nat Cell Biol
Main Authors: Ertych, Norman, Stolz, Ailine, Stenzinger, Albrecht, Weichert, Wilko, Kaulfuß, Silke, Burfeind, Peter, Aigner, Achim, Wordeman, Linda, Bastians, Holger
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389786/
https://ncbi.nlm.nih.gov/pubmed/24976383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2994
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