Protective immunity against influenza H5N1 virus challenge in chickens by oral administration of recombinant Lactococcus lactis expressing neuraminidase

BACKGROUND: Highly pathogenic H5N1 avian influenza viruses pose a debilitating pandemic threat in poultry. Current influenza vaccines predominantly focus on hemagglutinin (HA) which anti-HA antibodies are often neutralizing, and are used routinely to assess vaccine immunogenicity. However, Neuramini...

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Bibliographic Details
Published in:BMC Vet Res
Main Authors: Lei, Han, Peng, Xiaojue, Ouyang, Jiexiu, Zhao, Daxian, Jiao, Huifeng, Shu, Handing, Ge, Xinqi
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389297/
https://ncbi.nlm.nih.gov/pubmed/25880824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-015-0399-4
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