Potent degradation of neuronal miRNAs induced by highly complementary targets

MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to A...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: de la Mata, Manuel, Gaidatzis, Dimos, Vitanescu, Mirela, Stadler, Michael B, Wentzel, Corinna, Scheiffele, Peter, Filipowicz, Witold, Großhans, Helge
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2015
Sujets:
Scientific Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388616/
https://ncbi.nlm.nih.gov/pubmed/25724380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540078
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