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Potent degradation of neuronal miRNAs induced by highly complementary targets
MicroRNAs (miRNAs) regulate target mRNAs by silencing them. Reciprocally, however, target mRNAs can also modulate miRNA stability. Here, we uncover a remarkable efficacy of target RNA-directed miRNA degradation (TDMD) in rodent primary neurons. Coincident with degradation, and while still bound to A...
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| Vydáno v: | EMBO Rep |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BlackWell Publishing Ltd
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4388616/ https://ncbi.nlm.nih.gov/pubmed/25724380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540078 |
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