Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo

Active molecular targeting has become an important aspect of nanoparticle development for oncology indications. Here, we describe molecular targeting of iron oxide nanoparticles (IONPs) to the folate receptor alpha (FOLRα) using an engineered antibody fragment (Ffab). Compared to control nanoparticl...

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Dades bibliogràfiques
Publicat a:Int J Nanomedicine
Autors principals: Ndong, Christian, Toraya-Brown, Seiko, Kekalo, Katsiaryna, Baker, Ian, Gerngross, Tillman U, Fiering, Steven N, Griswold, Karl E
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388088/
https://ncbi.nlm.nih.gov/pubmed/25878495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S79367
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