Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo

Active molecular targeting has become an important aspect of nanoparticle development for oncology indications. Here, we describe molecular targeting of iron oxide nanoparticles (IONPs) to the folate receptor alpha (FOLRα) using an engineered antibody fragment (Ffab). Compared to control nanoparticl...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Ndong, Christian, Toraya-Brown, Seiko, Kekalo, Katsiaryna, Baker, Ian, Gerngross, Tillman U, Fiering, Steven N, Griswold, Karl E
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388088/
https://ncbi.nlm.nih.gov/pubmed/25878495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S79367
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