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Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer’s disease: Insights into why statins might not provide clinical benefit

Altered cholesterol homeostasis in general and increased levels of low-density lipoprotein (LDL) cholesterol specifically is a robust risk factor for the pathogenesis of sporadic Alzheimer’s disease (AD). Because of this, the family of drugs known as statins have been tried extensively to lower chol...

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Библиографические подробности
Опубликовано в: :Austin J Pharmacol Ther
Главные авторы: Chen, Xuesong, Hui, Liang, Geiger, Jonathan D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387891/
https://ncbi.nlm.nih.gov/pubmed/25859562
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