Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

Accumulation of abnormal protein inclusions is implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Autophagy, an intracellular process targeting misfolded proteins and damaged organelles for lysosomal degradation, plays crucial roles in survival and diseased conditions. E...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Xiao, Yajuan, Ma, Changling, Yi, Jianxun, Wu, Shaoping, Luo, Guo, Xu, Xiulong, Lin, Pei‐Hui, Sun, Jun, Zhou, Jingsong
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Periodicals, Inc. 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387765/
https://ncbi.nlm.nih.gov/pubmed/25602021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12271
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