Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

Accumulation of abnormal protein inclusions is implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Autophagy, an intracellular process targeting misfolded proteins and damaged organelles for lysosomal degradation, plays crucial roles in survival and diseased conditions. E...

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Pubblicato in:Physiol Rep
Autori principali: Xiao, Yajuan, Ma, Changling, Yi, Jianxun, Wu, Shaoping, Luo, Guo, Xu, Xiulong, Lin, Pei‐Hui, Sun, Jun, Zhou, Jingsong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Periodicals, Inc. 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387765/
https://ncbi.nlm.nih.gov/pubmed/25602021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12271
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