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Autoinhibitory mechanisms of ERG studied by molecular dynamics simulations

ERG, an ETS-family transcription factor, acts as a regulator of differentiation of early hematopoietic cells. It contains an autoinhibitory domain, which negatively regulates DNA-binding. The mechanism of autoinhibitory is still illusive. To understand the mechanism, we study the dynamical propertie...

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Detalhes bibliográficos
Publicado no:AIP Adv
Main Authors: Lu, Yan, Salsbury, Freddie R.
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387600/
https://ncbi.nlm.nih.gov/pubmed/25874157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4906572
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