Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (...

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Publicado en:J Exp Med
Main Authors: Dutta, Partha, Hoyer, Friedrich Felix, Grigoryeva, Lubov S., Sager, Hendrik B., Leuschner, Florian, Courties, Gabriel, Borodovsky, Anna, Novobrantseva, Tatiana, Ruda, Vera M., Fitzgerald, Kevin, Iwamoto, Yoshiko, Wojtkiewicz, Gregory, Sun, Yuan, Da Silva, Nicolas, Libby, Peter, Anderson, Daniel G., Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387283/
https://ncbi.nlm.nih.gov/pubmed/25800955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141642
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