Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

Alzheimer disease (AD) is characterized by deposits of an aggregated 42-amino-acid beta-amyloid peptide (beta AP) in the brain and cerebrovasculature. After a concentration-dependent lag period during in vitro incubations, soluble preparations of synthetic beta AP slowly form fibrillar aggregates th...

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Bibliographische Detailangaben
Hauptverfasser: Vitek, M P, Bhattacharya, K, Glendening, J M, Stopa, E, Vlassara, H, Bucala, R, Manogue, K, Cerami, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43869/
https://ncbi.nlm.nih.gov/pubmed/8197133
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