TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

Organelle ion homeostasis within the endo-lysosomal system is critical for physiological functions. Two-pore channels (TPCs) are cation channels that reside in endo-lysosomal organelles, and overexpression results in endo-lysosomal trafficking defects. However, the impact of a lack of TPC expression...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Ruas, Margarida, Chuang, Kai-Ting, Davis, Lianne C., Al-Douri, Areej, Tynan, Patricia W., Tunn, Ruth, Teboul, Lydia, Galione, Antony, Parrington, John
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386455/
https://ncbi.nlm.nih.gov/pubmed/25135478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00113-14
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