T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

During infection, the release of damage-associated molecular patterns, so-called “alarmins,” orchestrates the immune response. The alarmin IL-33 plays a role in a wide range of pathologies. Upon release, IL-33 signals through its receptor ST2, which reportedly is expressed only on CD4(+) T cells of...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Baumann, Claudia, Bonilla, Weldy V., Fröhlich, Anja, Helmstetter, Caroline, Peine, Michael, Hegazy, Ahmed N., Pinschewer, Daniel D., Löhning, Max
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386370/
https://ncbi.nlm.nih.gov/pubmed/25829541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418549112
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