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ATM prevents DSB formation by coordinating SSB repair and cell cycle progression
DNA single-strand breaks (SSBs) arise as a consequence of spontaneous DNA instability and are also formed as DNA repair intermediates. Their repair is critical because they otherwise terminate gene transcription and generate toxic DNA double-strand breaks (DSBs) on replication. To prevent the format...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386361/ https://ncbi.nlm.nih.gov/pubmed/25775545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416031112 |
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